Document Type
Article
Publication Date
11-2011
Abstract
The incidence of asthma is on the increase and calls for research are growing, yet asthma is a disease that scientists are still trying to come to grips with. Asthma research has relied heavily on animal use; however, in light of increasingly robust in vitro and computational models and the need to more fully incorporate the ‘Three Rs’ principles of Replacement, Reduction and Refinement, is it time to reassess the asthma research paradigm? Progress in non-animal research techniques is reaching a level where commitment and integration are necessary. Many scientists believe that progress in this field rests on linking disciplines to make research directly translatable from the bench to the clinic; a ‘21st-century’ scientific approach to address age-old questions.
Recommended Citation
Buckland, G. L. (2011). Harnessing opportunities in non-animal asthma research for a 21st-century science. Drug discovery today, 16(21), 914-927.
Included in
Bioethics and Medical Ethics Commons, Laboratory and Basic Science Research Commons, Research Methods in Life Sciences Commons
Comments
In compliance with the publisher’s copyright and archiving policies, this is a post-print version of the document. Post-print materials contain the same content as their final edited versions, but are not formatted according to the layout of the published book or journal.